Certificate in Cancer Immunotherapy Module 7: CAR T Cell and Cellular Therapy

Published 12/1/2021

 

Course Description
This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

This course, Module 7: CAR T Cell and Cellular Therapy, will cover the mechanisms and clinical administration of cellular therapies for cancer, including an emphasis on adverse event management.


Target Audience
The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

Faculty
Carl June, MD
Richard W. Vague Professor In Immunotherapy, Department of Pathology and Laboratory Medicine
Director, Parker Institute for Cancer Immunotherapy
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
 

Learning Objectives

Topic At the conclusion of this activity, the participant should be able to:

Basic Mechanisms of Adoptive T Cell Immunotherapy

  • Describe the biologic basis for adoptive T cell therapy of cancer.
  • Define significance of different target antigens and signaling moieties in CAR T cell activity.
  • Contrast the differences between CAR T and other adoptive T cell strategies.
  • Distinguish between different CAR T preparations such as target antigen but also viral vector culture conditions and signaling moieties.

Cellular therapies and Current Clinical Indications

  • Classify the types of adoptive T cell therapies approved for cancer treatment.
  • Describe clinical indications of approved therapies.
  • Describe off-label uses of CAR T cell therapy.

Patient Selection for
T Cell-based Therapy

  • Identify when patients should be referred for cellular therapy.
  • Recognize contraindications to adoptive cell administration.
  • Describe the timeline of adoptive cellular therapy preparation and administration.

Management of CAR T Cell
Administration and Adverse Events

  • Describe the preparation of CAR T and patient disease management prior to administration.
  • Recognize the different types and patterns of CAR T-related toxicity.
  • Outline approaches to monitoring patients for CAR T-related toxicity including cytokine release syndrome and neurotoxicity.
  • Describe grading and management of cytokine release syndrome and neurotoxicity.
  • Describe typical kinetics of response of malignancy to CAR T cell therapy.
  • Describe long term monitoring and management of CAR T cell patients including identification and management of long term toxicities such as cytopenias and immuno-deficiency.
  • Describe the resources required for outpatient management of CAR T cell therapy

Requirements for CAR T Cell Program Development

  • Describe the requirements for site certification for administering cellular therapies, including REMS training.
  • Identify other medical specialists who need to participate in REMS training and care of CAR T patients.
  • Outline data reporting requirements for CAR T cell programs.
  • Describe in-patient versus out-patient management and monitoring of CAR T cell patients.


 


SITC Online Education Disclaimer

 

A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

 



Continuing Education Information

Date of CE Release:  December 1, 2021
Date of CE Expiration: December 1, 2023
Approximate Time to Complete:  30 minutes

Acknowledgement of Financial Commercial Support
No financial commercial support was received for this educational activity.

Acknowledgement of In-Kind Commercial Support
No in-kind commercial support was received for this educational activity.

Satisfactory Completion

Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 75% or higher (unlimited attempts) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

Physicians / Nurses / Pharmacist

In support of improving patient care, this activity has been planned and implemented by Amedco LLC and SITC.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation  Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Credit Designation Statement – Amedco LLC designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditsTM for physicians, 0.50 contact hour for nurses, and 0.50 knowledge-based contact hour for pharmacists. Learners should claim only the credit commensurate with the extent of their participation in the activity.

NOTE to Pharmacists: The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 30 days of the activity to meet the deadline for submission to CPE Monitor.

UAN: JA4008163-9999-21-218-H04-P / JA4008163-9999-21-218-H04-T

ABIM MOC Credit
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 Part 2 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program.

Disclosure of Conflict of Interest
The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco.  All of these relationships were treated as a conflict of interest, and have been resolved.  (C7 SCS 6.1-­6.2, 6.5)

All individuals in a position to control the content of CE are listed online. If their name is not listed below, they disclosed that they had no relevant financial relationships.

FIRST NAME

LAST NAME

RELATIONSHIP:COMMERCIAL INTEREST

Jennifer Brudno NA
Umar Farooq Kite Pharma: Consulting
Meredith Ginn NA
Carl June Novartis: Royalties; AC Immune, Bluesphere Bio, Cellares, Celldex, Cabaletta, Carisma, DeCART, Kiadis, Poseida, Viracta, WIRB-Copernicus Group: Consulting
Huma Kahn NA
Tiffany Klopp NA
Claire Leischer NA
Scott McGee-Plys NA
Jill Wall NA

Method of Participation and Request for Credit
During the period 12/1/2021 through 12/1/2023 participants must read the learning objectives and faculty disclosures and study the educational activity.

Once the participant has passed the post-test with a score of 80% or higher (unlimited attempts allowed), and the course evaluation has been completed, credit will be automatically requested to the CRO the participant has selected during the registration process. 

Certificates will be available to the participant for printing after passing the post-test and completing the course evaluation.

For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


Media
Internet

Hardware and Software Requirements
SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.

Disclosure of Unlabeled Use
This educational activity may contain a discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Certificate in Cancer Immunotherapy Module 7: CAR T Cell and Cellular Therapy

Next, to view the course, close this window and you will be taken to the course menu page. Once there, refresh the course menu page and select View Now for the last topic.

Individual topic purchase: Selected
Accreditation Council for Continuing Medical Education (MD/DO)
AMA PRA Category 1 Credit(s)™: 0.50
Accreditation Council for Continuing Medical Education (non-MD/DO)
AMA PRA Category 1 Credit(s)™: 0.50
Certificate of Participation (No Credit)
Certificate of Participation: 0.00
Accreditation Council for Continuing Medical Education and ABIM Maintenance of Certification
AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit: 0.50
Accreditation Council for Pharmacy Education
Contact Hour: 0.50
American Nurses Credentialing Center's Commission on Accreditation
Contact Hour: 0.50
Products
Certificate in Cancer Immunotherapy Module 7: CAR T Cell and Cellular Therapies
SITC Member Price:$25.00
Non-Member Price:$31.25