Gynecologic Cancer CPG Mini Module – Immunotherapy Biomarkers in the Gynecologic Tract: MMR, PD-L1, and TMB

The SITC Cancer Immunotherapy Guidelines Webinars connect clinicians with leading experts in the field and provide education about the evidence- and consensus-based recommendations in the clinical practice guidelines. To complement the advanced live webinar series, three on-demand, mini modules will assist learners in applying lessons learned on specific topics within the use of immunotherapy in their own practices and locate additional resources to continue their education.

Anne M. Mills, MD, of the University of Virginia, provides a comprehensive overview of three biomarkers associated with immunotherapy for gynecologic cancers, specifically mismatch repair (MMR), PD-L1, and tumor mutation burden (TMB). Topics discussed include immunohistochemistry- and PCR-based testing for these biomarkers, interpretation of test results, and limitations associated with these testing methods, especially in the context of gynecologic cancers. The recommendations for immunotherapy testing of biomarkers based on tumor type and studies supporting these recommendations are also discussed and summarized. The Mini-Module ends with a discussion between Dr. Mills and Nora Disis, MD, FACP, of the University of Washington on the potential of total tumor DNA sequencing for detecting biomarkers

Run time: Approximately 20 minutes

Target Audience
Clinicians and advanced practice providers who treat cancer patients are the target audience, including community physicians, oncologists, emergency room physicians, disease specialists, registered nurses, nurse practitioners, pharmacists, physician assistants, and radiologists. 

SITC Online Education Disclaimer
A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described
in this educational activity. 

The Quick Education Modules are part of the Cancer Immunotherapy Clinical Practice Guidelines Advanced Webinar Series supported, in part, by grants from Amgen and Merck & Co., Inc. (as of 09/07/2023). 

The SITC Clinical Practice Guidelines are produced and funded solely by SITC. No outside funding is received for the development of the manuscripts.