Certificate in Cancer Immunotherapy Module 2: Basic Cancer Immunotherapy Concepts

Check out our updated version- Certificate in Cancer Immunotherapy - Module 2 (As of 11/14/2022*), Available now....

  • Certificate in Cancer Immunotherapy Module 2: Basic Cancer Immunotherapy Concepts
  • Release Date: October 26, 2020
  • Expiration Date: October 26, 2024
  • Date of Last Review: 10/12/2023
  • Jointly provided by Partners for Advancing Clinical Education (PACE) and Society for Immunotherapy of Cancer (SITC)
  • Estimated time to complete the activity: 90 minutes
  • For additional information about the accreditation of this activity, please visit https://partnersed.com
  • Computer system hardware/software requirements: SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.


Course Description
This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

This course, Module 2: Basic Cancer Immunotherapy Concepts, will cover the biological foundation of cancer immunotherapy, applying the basic immunology you learned in the last module to help lay the foundation for future topics in this program.

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Target Audience
The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

Educational Objectives                                                   

Upon completion of this activity, participants should be able to:

Basis of Tumor Immunosurveillance and Immunotherapy

  • Describe how the immune system recognizes and eliminates cancer cells, including the concept of immunologic memory.
  • Characterize the function of specific immune cell populations in mediating tumor immunotherapy and/or immune suppression.
  • Distinguish between immunosurveillance, immunoediting and immunotherapy of cancer.
  • Identify the implications of immune depleted, excluded and infiltrated tumor microenvironments.
  • Identify how both central and peripheral tolerance can impact immunosurveillance and immunotherapy.
  • Describe the difference between primary and acquired resistance to immunotherapy.
  • Apply concepts of the cancer-immunity cycle to identify how biomarkers inform and influence tumor immunotherapy.


Immunologic effects of other therapies

  • Describe the immunologic effects of standard cancer therapeutics on the tumor microenvironment and immune system.
  • Describe the potential impact of other, non-cancer agents, on tumor immunotherapy responses and toxicities.
  • Characterize the impact of standard cancer treatments on the efficacy of cancer immunotherapy.
  • Characterize the impact of standard cancer treatments on the toxicity of cancer immunotherapy.
  • Distinguish total body versus focal radiotherapy effects.
  • Recognize the impact of intratumoral injection and other local therapies on the tumor microenvironment and anti-tumor immune response.


SITC Online Education Disclaimer
A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.


Faculty and Disclosure of Conflicts of Interest
PACE requires planners, faculty, and others who are in a position to control the content of this activity to disclose all financial relationships they may have with ineligible companies. All relevant financial relationships are thoroughly vetted and mitigated according to PACE policy. PACE is committed to providing learners with high-quality accredited CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.


The faculty reported the following financial relationships or relationships to products or devices they have with ineligible companies:


Presenting Faculty

Conflict of Interest

Hussein Tawbi, MD, PhD
Deputy Chair and Professor, Department of Melanoma Medical Oncology
Director of Melanoma Clinical Research & Early Drug Development
Co-Director, MD Anderson Brain Metastasis Clinic
University of Texas MD Anderson Cancer Center, Houston, TX

  • Consultant: Genentech, BMS, Novartis, Merck, Array
  • Contracted Research: Genentech, BMS, Novartis, Merck, GSK



Certificate Program Task Force

Conflict of Interest

Robert L. Ferris, MD, PhD (Chair)
UPMC Hillman Cancer Center

  • Researcher: Astra-Zeneca/Medimmune, Bristol Myers Squibb, Merck, Novasenta, Tesaro
  • Consultant/Advisor/Speaker: Achilles Therapeutics; Adagene Incorporated, Adaptimmune, Aduro Biotech Inc, Astra-Zeneca/MedImmune; Bicara Therapeutics, Inc, Bristol-Myers Squibb, Brooklyn Immunotherapeutic, Cantenion, Coherus BioSciences, Inc, CureVac, Cytoagents, Eisai Europe Limited, EMD Serono, Everest Clinical Research Corporation, F. Hoffman-La Roche Ltd., Federation Bio, Inc, Genmab, Genocea Biosciences, Inc, Hookipa Biotech GmbH, Instill Bio, Inc, Kowa Research Institute, Inc, Lifescience Dynamics Limited, MacroGenics, Inc, MeiraGTx, LLC, Merck, Merus N.V, Mirati Therapeutics, Inc, Mirror Biologics Inc, Nanobiotix, Novartis Pharmaceutical Corporation, Novasenta, Numab Therapeutics AG, OncoCyte Corporation, Pfizer, PPD Development, L.P., Rakuten Medical, Inc, Regeneron, Sanofi, Seagen, Inc, SIRPant Immunotherapeutics, Inc, Tesaro, Vir Biotechnology, Inc, Zymeworks Inc
  • Stock holder: Novasenta

Umar Farooq, MD
University of Iowa

  • Researcher: Regeneron Pharmaceuticals
  • Consultant/Advisor/Speaker: Immpact Bio, Caribou Biosciences, Kite Pharma, MoprhoSys

Silvia Formenti, MD
Weill Cornell Medicine

  • Grant/Research Support: Bristol Myers Squibb, Varian, Regeneron, Merck, Celldex, ViewRay, AstraZeneca
  • Consultant/Honoraria: Bayer, Bristol Myers Squibb, Varian, ViewRay, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, Astra Zeneca, MedImmune, Merck US, EMD Serono/Merck, Genentech/ROCHE, Nanobiotix

Sigrun Hallmeyer, MD
Advocate Medical Group

  • Consultant: Cardinal Health

Jose Lutzky, MD, FACP
University of Miami Sylvester Cancer Center

  • Researcher: BMS
  • Consultant/Advisor/Speaker: Castle, Iovance, Vyriad, Replimune, Takeda, Oncotelic, T-Nanobio, Agenus, Celldex
  • Independent Contractor: BMS, Novartis, Iovance, Replimune, Regeneron, InstilBio, Syntrix, BioNtech, Foghorn, Trisalus, Agenus, Inmatics, Takeda, Dragonfly

George Weiner, MD
University of Iowa

  • Researcher: Regeneron, Pfizer



The PACE planners and others have no relevant financial relationship(s) to disclose with ineligible companies. The SITC planners and others have no relevant financial relationship(s) to disclose with ineligible companies.


Instruction for Credit

During the period 10/27/2023 through 10/27/24 participants must read the learning objectives and faculty disclosures and study the educational activity.

Once the participant has passed the post-test with a score of 80% or higher (unlimited attempts allowed), and the course evaluation has been completed, credit will be automatically requested to the CRO the participant has selected during the registration process.
Certificates will be available to the participant for printing after passing the post-test and completing the course evaluation.


Satisfactory Completion
Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 80% or higher (unlimited attempts) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.


Joint Accreditation Statement
Physicians / Nurses / Pharmacists

In support of improving patient care, this activity has been planned and implemented by Partners for Advancing Clinical Education (PACE) and Society for Immunotherapy of Cancer (SITC).  PACE is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.



Physician Continuing Education
PACE designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine (ABIM) Maintenance of Certification
A close up of a signDescription automatically generated Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.


Nursing Continuing Professional Development
The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 1.5 contact hours.


Pharmacy Continuing Education
PACE designates this continuing education activity for 1.5 contact hour(s) (0.1 CEUs) of the Accreditation Council for Pharmacy Education.
(Universal Activity Number - JA4008073-9999-23-272-H01-P)
Type of Activity: Knowledge

For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


Medical Physicist (CAMPEP)
This program has been approved by The Commission on Accreditation of Medical Physics Education Programs (CAMPEP) for 1.50 MPCEC Hours.

You must request your certificate within 30 days of the activity to meet the deadline for submission to PARS.




Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Certificate in Cancer Immunotherapy Module 2: Basic Cancer Immunotherapy Concepts

Next, to view the course, close this window and you will be taken to the course menu page. Once there, refresh the course menu page and select View Now for the last topic.


Individual topic purchase: Selected
Accreditation Council for Continuing Medical Education (MD/DO)
AMA PRA Category 1 Credit(s)™: 1.50
Accreditation Council for Continuing Medical Education (non-MD/DO)
AMA PRA Category 1 Credit(s)™: 1.50
Certificate of Participation (No Credit)
Certificate of Participation: 0.00
Accreditation Council for Continuing Medical Education and ABIM Maintenance of Certification
AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit: 1.50
Accreditation Council for Pharmacy Education
Contact Hour: 1.50
American Nurses Credentialing Center's Commission on Accreditation
Contact Hour: 1.50
Commission on Accreditation of Medical Physics Education Programs
Medical Physics Continuing Education Credit: 1.50
Certificate in Cancer Immunotherapy Module 2: Basic Cancer Immunotherapy Concepts